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Information for Health Care Providers

Hepatitis A Vaccine and Pregnancy

Pregnant women who may have been exposed to the hepatitis A virus and who are not already vaccinated against it should receive both the hepatitis A vaccine and immune globulin (IG) to prevent infection. This guidance is based on the recommendations of the Centers for Disease Control and Prevention and the Michigan Department of Health and Human Services.   

Safety of Hepatitis A Vaccine and Immune Globulin (IG) During Pregnancy:

Hepatitis A Vaccine
The safety of hepatitis A vaccination during pregnancy has not been determined; however, because hepatitis A vaccine is produced from inactivated HAV, the theoretic risk to the developing fetus is expected to be low. The risk associated with vaccination should be weighed against the risk for hepatitis A in pregnant women who might be at high risk for exposure to HAV https://www.cdc.gov/vaccines/pregnancy/hcp/guidelines.html#hepa

 

Immune Globulin (IG)
Serious adverse events from IG are rare. Anaphylaxis has been reported after repeated administration to persons with known immunoglobulin A (IgA) deficiency; thus, IG should not be administered to these persons. Pregnancy or lactation is not a contraindication to IG administration https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5507a1.htm

Reference: CDC. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2006; 55 (No. RR-7): 15.

Additional Information:

“Update: Prevention of Hepatitis A After Exposure to Hepatitis A Virus and in International Travelers. Updated Recommendations of the Advisory Committee on Immunization Practices (ACIP).” MMWR. October 19, 2007 /56(41); 1080-1084. Available at https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5641a3.htm   

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